Description

S-Mandelylglutathione is a specialized glutathione derivative where the S-mandelic acid moiety is conjugated to the thiol group of glutathione. This compound is significant for its role as a model substrate and intermediate in biochemical research, particularly in studies related to enzyme kinetics, detoxification pathways, and cellular redox mechanisms. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for developing analytical methods and investigating metabolic processes.

Application

• Biochemical Research: Used as a reference standard or substrate in enzymatic assays to study glutathione S-transferase (GST) activity and related detoxification pathways.
• Pharmaceutical Intermediates: Serves as a key chiral building block or precursor in the synthesis of more complex bioactive molecules and potential therapeutic agents.
• Metabolite Studies: Employed in metabolic profiling and research to understand the conjugation and excretion pathways of xenobiotics and endogenous compounds.
• Analytical Standard: Acts as a high-purity calibration standard in chromatographic methods (HPLC, LC-MS) for quantitative analysis in complex biological matrices.
• Antioxidant Mechanism Research: Investigated for its role in cellular redox balance and as a tool to probe oxidative stress responses and antioxidant defense systems.

Basic Information

Product Name	S-Mandelylglutathione
CAS No.	50409-83-1
Molecular Formula	C18H25N3O8S
Molecular Weight	443.47 g/mol
Synonyms	S-(α-Hydroxybenzyl)glutathione; L-γ-Glutamyl-S-(α-hydroxybenzyl)-L-cysteinylglycine; Glutathione S-(α-hydroxybenzyl) conjugate; Mandelyl-glutathione; S-(Mandeloyl)glutathione; GST substrate analog; (2S)-2-Amino-5-[[(2R)-1-[[(1S)-1-carboxy-2-(α-hydroxybenzylthio)ethyl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our S-Mandelylglutathione is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) that include data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards suitable for research and development applications, and custom purity grades are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.