Description

8,2'-S-Cycloinosinyl-(3',5')-8,2'-S-Cycloadenosine is a chemically modified dinucleotide, a sophisticated building block in nucleic acid chemistry. This compound is valued for its unique bridged structure, which imparts enhanced stability and specific binding properties, making it a critical intermediate for advanced research and development. It is primarily utilized by pharmaceutical researchers and biotechnology companies focused on oligonucleotide synthesis, drug discovery, and the development of novel therapeutic agents and diagnostic tools.

Application

• Oligonucleotide Synthesis: Serves as a specialized phosphoramidite or solid-phase synthesis intermediate for creating modified RNA/DNA strands with enhanced nuclease resistance and binding affinity.
• Antisense & RNA Therapeutics: Used in the research and development of antisense oligonucleotides, siRNA, and other RNA-based therapeutic platforms where structural modification is key to efficacy and stability.
• Structural Biology Studies: Acts as a probe or model compound to study nucleic acid conformation, dynamics, and protein-nucleic acid interactions.
• Diagnostic Probe Development: Incorporated into the design of high-specificity probes for molecular diagnostics, including FISH and PCR-based assays.
• Medicinal Chemistry & Drug Discovery: Employed as a key scaffold in the search for new small-molecule or nucleotide-based drugs targeting various enzymes and receptors.
• Bioconjugation & Labeling: Provides a reactive handle for attaching reporter molecules, tags, or other functional groups to oligonucleotides.

Basic Information

Product Name	8,2'-S-Cycloinosinyl-(3',5')-8,2'-S-Cycloadenosine
CAS No.	50271-86-8
Molecular Formula	C20H22N10O10S
Molecular Weight	594.52 g/mol
Synonyms	8,2'-S-Cycloadenylyl-(3',5')-8,2'-S-cycloinosine; Cyclic Adenylyl-Inosine Dinucleotide; 8,2'-Thio-bridged Adenosine-Inosine Dimer; 8,2'-S-Cyclo-AI; 8,2'-S-Cyclo(adenylyl-inosine); 8,2'-S-Cyclo(ApI); 8,2'-S-Cyclo(adenosine-inosine) dinucleotide; 8,2'-S-Cyclo(A-I)
EINECS	Contact for details

Quality Control

Our production of 8,2'-S-Cycloinosinyl-(3',5')-8,2'-S-Cycloadenosine adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.