Description

Apoatropine Hydrochloride is a high-purity pharmaceutical reference standard and active pharmaceutical ingredient (API) derived from atropine. This compound is critical for analytical research, method development, and quality control in pharmaceutical manufacturing, ensuring the accuracy and reliability of test results. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies involved in the development and production of anticholinergic agents and related therapeutic compounds.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification, assay, and impurity profiling of atropine and related tropane alkaloids in drug substances and products via HPLC, GC, or LC-MS.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic intermediate or starting material in the research and development of novel anticholinergic and antispasmodic drugs.
• Biochemical Research: Employed in pharmacological studies to investigate muscarinic acetylcholine receptor (mAChR) antagonism, autonomic nervous system function, and the mechanisms of anticholinergic agents.
• Analytical Method Development: Essential for developing and validating chromatographic and spectroscopic methods in quality control laboratories to ensure compliance with pharmacopeial monographs (e.g., USP, EP).
• Forensic and Toxicology Analysis: Used as an analytical standard for the detection and quantification of tropane alkaloids in forensic samples and toxicological screenings.

Basic Information

Product Name	Apoatropine Hydrochloride
CAS No.	5978-81-4
Molecular Formula	C17H22ClNO2
Molecular Weight	307.82 g/mol
Synonyms	Apoatropine HCl; Atropamine Hydrochloride; DL-Apoatropine Hydrochloride; (8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate Hydrochloride; Tropatropine Hydrochloride; Aposcopolamine Hydrochloride; NSC 406042; Atropyltropeine Hydrochloride
EINECS	227-795-8

Quality Control

Our Apoatropine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.