Description

Berberine Chloride Dihydrate is a quaternary ammonium salt of the isoquinoline alkaloid berberine, widely recognized for its broad-spectrum biological activity. This high-purity compound is essential for research and development in the pharmaceutical and nutraceutical sectors, where consistent quality and reliable supply are paramount. It is primarily sought by manufacturers and research institutions focused on metabolic health, antimicrobial formulations, and natural product standardization.

Application

• Pharmaceutical Intermediates: Serves as a key active pharmaceutical ingredient (API) or precursor in formulations targeting metabolic syndrome, diabetes, and cardiovascular health.
• Dietary Supplements & Nutraceuticals: Used as a standardized botanical extract in capsules, tablets, and liquid formulations for its well-documented health-supporting properties.
• Biochemical & Life Science Research: A critical reagent for in-vitro and in-vivo studies investigating mechanisms of action related to AMPK activation, glucose metabolism, and antimicrobial effects.
• Reference Standards & Analytical Testing: Employed as a high-purity certified reference material (CRM) for quality control and assay development in analytical laboratories.
• Cosmeceutical Applications: Incorporated into topical formulations for its potential anti-inflammatory and skin-brightening properties.
• Veterinary Medicine: Used in animal health products for its antimicrobial and anti-diarrheal benefits.

Basic Information

Product Name	Berberine Chloride Dihydrate
CAS No.	5956-60-5
Molecular Formula	C20H18ClNO4 · 2H2O
Molecular Weight	407.82 g/mol
Synonyms	Berberine Hydrochloride Dihydrate; Berberine HCl Dihydrate; 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium Chloride Dihydrate; Umbellatine Chloride Dihydrate; Natural Yellow 18 Chloride Dihydrate
EINECS	Contact for details

Quality Control

Our Berberine Chloride Dihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, to ensure it meets stringent specifications for pharmaceutical and research applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	7.0% - 10.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.