Description

Cinchonine Hydrochloride is a high-purity alkaloid salt derived from cinchona bark, serving as a critical chiral building block and resolving agent. Its primary value lies in its ability to induce and study stereoselective reactions, making it indispensable for asymmetric synthesis and analytical method development. This compound is essential for research and production in the pharmaceutical, fine chemical, and academic sectors, where precise chiral control is paramount.

Application

• Chiral Resolution Agent: Used for the separation of racemic mixtures of carboxylic acids and other chiral compounds.
• Asymmetric Synthesis Catalyst: Acts as a chiral catalyst or ligand in stereoselective organic transformations.
• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those with quinuclidine or quinoline motifs.
• Analytical Chemistry Standard: Employed as a reference standard in HPLC and other chromatographic methods for method validation and quality control.
• Biochemical Research: Used in studies of biological systems and as a tool compound in pharmacological research.
• Fine Chemical Synthesis: A valuable reagent for the preparation of complex, optically active molecules in specialty chemistry.

Basic Information

Product Name	Cinchonine Hydrochloride
CAS No.	5949-12-2
Molecular Formula	C19H22N2O · HCl
Molecular Weight	322.85 g/mol (Free base: 294.39)
Synonyms	(8α,9R)-Cinchonan-9-ol Hydrochloride; Cinchonine HCl; Cinchonine Monohydrochloride; (8α,9R)-6'-Methoxycinchonan-9-ol Hydrochloride; α-(2-Quinolyl)-5-vinyl-2-quinuclidinemethanol Hydrochloride; (9R)-Cinchonine Hydrochloride; NSC 132990
EINECS	227-706-7

Quality Control

Our Cinchonine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets exacting standards for research and industrial use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Specific Rotation [α]20/D	Contact for details
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.