Description

Cinchonine Hydrochloride is a high-purity alkaloid salt derived from cinchona bark, serving as a critical chiral building block and resolving agent in advanced organic synthesis. Its primary commercial value lies in its ability to induce and control stereoselectivity, a fundamental requirement for producing enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for research and production laboratories in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular configuration dictates product efficacy and safety.

Application

• Chiral Resolution Agent: Used for the separation of racemic mixtures of carboxylic acids and other chiral compounds.
• Asymmetric Synthesis Catalyst: Employed as a chiral ligand or catalyst in stereoselective chemical reactions.
• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those with quinuclidine or quinoline scaffolds.
• Analytical Chemistry Standard: Utilized as a reference standard in HPLC and other chromatographic methods for method development and quality control.
• Biochemical Research: Applied in studies of biological systems and as a tool compound in pharmacological research.
• Agrochemical Synthesis: Used in the development of enantiomerically pure pesticides and herbicides.

Basic Information

Product Name	Cinchonine Hydrochloride
CAS No.	5949-11-1
Molecular Formula	C19H22N2O • HCl
Molecular Weight	322.85 g/mol (Free base: 294.39)
Synonyms	Cinchonan-9-ol, (8α,9R)-, hydrochloride (1:1); (8α,9R)-Cinchonan-9-ol hydrochloride; Cinchonine HCl; Cinchonine monohydrochloride; (+)-Cinchonine hydrochloride; α-(2-Quinuclidinyl)-4-quinolinemethanol hydrochloride
EINECS	227-705-5

Quality Control

Our Cinchonine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity assessment, and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards for research and industrial use. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.