Description

Desulfo Coenzyme A is a key biochemical intermediate and a structural analog of the essential cofactor Coenzyme A (CoA). This compound is vital for research into enzymatic mechanisms, particularly those involving acyl group transfer, as it lacks the reactive thiol group. It serves as a crucial tool for scientists and manufacturers in the life sciences sector, enabling the study and development of metabolic pathways, enzyme inhibitors, and diagnostic assays. Primary demand comes from pharmaceutical R&D, biotechnology, and academic research institutions focused on biochemistry and molecular biology.

Application

• Biochemical Research: Used as a substrate analog in enzymatic studies to investigate the mechanism of CoA-dependent enzymes like acetyl-CoA synthetase and acyl-CoA dehydrogenases.
• Pharmaceutical Development: Serves as a reference standard and starting material in the synthesis of novel enzyme inhibitors targeting metabolic disorders and cancers.
• Diagnostic Reagent Manufacturing: Employed in the formulation of assay kits for clinical diagnostics that measure CoA or CoA-dependent enzyme activity.
• Metabolic Pathway Analysis: A critical tool in in vitro studies to map and understand complex metabolic networks, including fatty acid synthesis and oxidation.
• Enzyme Kinetics: Utilized to determine kinetic parameters and inhibition constants (Ki) for CoA-utilizing enzymes without the complication of disulfide bond formation.
• Academic & Educational Use: A standard reagent in university laboratories for teaching advanced concepts in coenzyme chemistry and enzymology.

Basic Information

Product Name	Desulfo Coenzyme A
CAS No.	5863-40-1
Molecular Formula	C21H36N7O16P3
Molecular Weight	767.47 g/mol
Synonyms	De(sulfo)coenzyme A; Coenzyme A, desulfo-; 3'-Dephospho-CoA; Desulpho-CoA; Adenosine 3'-(dihydrogen diphosphate) 5'-(3-((3-((2-((2-(acetylamino)-2-carboxyethyl)thio)-1-oxopropyl)amino)-3-oxopropyl)amino)-3-oxopropyl dihydrogen diphosphate); Dethiocoenzyme A; NSC 75947; 3'-Dephospho-coenzyme A
EINECS	227-506-4

Quality Control

Our Desulfo Coenzyme A is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and stringent tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For specific purity requirements (e.g., >95%, >98%), please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For extended storage under inert atmosphere, please inquire.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.