Description

Reverse T3 CAS NO 5817-39-0 is a high-purity thyroid hormone analog, specifically the 3,3',5'-triiodo-L-thyronine isomer. This compound is a critical reference standard and research chemical for investigating thyroid hormone metabolism, receptor binding, and endocrine signaling pathways. It is essential for pharmaceutical R&D, clinical diagnostics, and academic research focused on metabolic disorders and hormone action.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and assay validation of thyroid hormone preparations and diagnostic kits.
• Endocrinology Research: A vital tool for studying the mechanisms of thyroid hormone action, metabolism, and the role of specific deiodinase enzymes in converting T4 to active and inactive metabolites.
• Diagnostic Reagent Manufacturing: Employed in the production and calibration of immunoassays (e.g., ELISA, RIA) for the accurate detection and quantification of thyroid hormones in clinical samples.
• Biochemical Studies: Utilized in receptor binding assays to investigate ligand-receptor interactions and the specificity of thyroid hormone receptors (TRα and TRβ).
• Metabolic Pathway Analysis: Applied in cell culture and animal models to elucidate the physiological and pathological roles of reverse T3 in conditions like non-thyroidal illness syndrome (NTIS) or euthyroid sick syndrome.

Basic Information

Product Name	Reverse T3
CAS No.	5817-39-0
Molecular Formula	C15H12I3NO4
Molecular Weight	650.97 g/mol
Synonyms	3,3',5'-Triiodo-L-thyronine; 3,3',5'-Triiodothyronine; rT3; Reverse Triiodothyronine; (2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid; 3,3',5'-T3; 3,3',5'-Triiodo-L-thyronine
EINECS	227-368-5

Quality Control

Our Reverse T3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and pharmaceutical reference standard requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.