Description

Phenylthiohydantoin-δ-Threonine is a specialized derivative of threonine, a crucial amino acid, modified with a phenylthiohydantoin group. This modification is significant for its role as a key intermediate and analytical standard in advanced peptide and protein research, particularly in sequencing and structural analysis. It is essential for research laboratories, pharmaceutical development units, and fine chemical synthesis operations focused on proteomics and analytical chemistry.

Application

• Peptide Sequencing Reagent: Used in the Edman degradation process for the stepwise determination of amino acid sequences in peptides and proteins.
• Analytical Reference Standard: Serves as a high-purity standard for calibrating analytical instruments like HPLC and mass spectrometry in proteomics research.
• Biochemical Research Intermediate: Acts as a critical building block in the synthesis of modified peptides and for studying protein structure-function relationships.
• Pharmaceutical Development: Employed in the research and development of novel peptide-based therapeutics and diagnostic agents.
• Proteomics and Metabolomics: Facilitates the identification and quantification of protein modifications and amino acid derivatives in complex biological samples.

Basic Information

Product Name	Phenylthiohydantoin-δ-Threonine
CAS No.	5800-50-0
Molecular Formula	C₁₁H₁₂N₂O₃S
Molecular Weight	252.29 g/mol
Synonyms	PTH-Threonine; PTH-δ-Thr; 3-[(Phenylamino)(thioxo)methyl]amino]-2-hydroxybutanoic acid; δ-Threonine Phenylthiohydantoin; Edman Degradation Product of Threonine; 2-Hydroxy-3-[(phenylcarbamothioyl)amino]butanoic acid; Phenylthiocarbamoyl-threonine
EINECS	Contact for details

Quality Control

Our Phenylthiohydantoin-δ-Threonine is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for sensitive analytical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of atmospheric moisture, which can affect stability and analytical performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.