Description

Brucine Hydrochloride is a high-purity alkaloid salt derived from *Strychnos nux-vomica*. This compound is valued for its specific pharmacological and biochemical properties, serving as a critical reference standard and research reagent. It is primarily utilized by pharmaceutical R&D laboratories, analytical chemistry facilities, and academic institutions engaged in neuroscience and toxicology studies. The product is supplied with full traceability and quality documentation to support rigorous scientific work.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments and the qualitative/quantitative analysis of related alkaloids in drug development and quality control.
• Biochemical Research: Employed in neuroscience studies as a selective antagonist for certain glycine receptors, aiding in the investigation of neurological pathways and signal transduction.
• Analytical Chemistry: Serves as a critical reagent in method development and validation for chromatographic techniques like HPLC and LC-MS in forensic and pharmaceutical analysis.
• Toxicology Studies: Used as a model compound in metabolic and toxicokinetic research to understand the effects and detection of strychnine-related alkaloids.
• Chemical Synthesis: Acts as a chiral building block or intermediate in the synthesis of more complex molecules for medicinal chemistry applications.

Basic Information

Product Name	Brucine Hydrochloride
CAS No.	5786-96-9
Molecular Formula	C23H26N2O4·HCl
Molecular Weight	430.92 g/mol
Synonyms	10,11-Dimethoxystrychnine Hydrochloride; 2,3-Dimethoxystrychnidin-10-one Hydrochloride; Brucine HCl; Strychnidin-10-one, 2,3-dimethoxy-, hydrochloride; Brucine hydrochloride hydrate (common form); NSC 406087; (-)-Brucine hydrochloride
EINECS	227-311-5

Quality Control

Every batch of Brucine Hydrochloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for research and reference materials. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay, related substances, and residual solvents. Our quality protocols are designed to support compliance with global regulatory expectations for analytical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Water (KF)	≤5.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Individual unknown impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.