Description

Tetrahydrohomofolic Acid CAS NO 5786-82-3 is a key biochemical intermediate and a reduced form of folic acid. This compound is of significant importance in pharmaceutical research and development, particularly in the study of folate metabolism and the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in the development of metabolic modulators, antifolate drugs, and advanced biochemical studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced folate analogs and targeted chemotherapeutic agents.
• Biochemical Research: Used as a standard or reagent in studies investigating folate metabolism, enzyme inhibition, and one-carbon transfer pathways.
• Metabolic Studies: Employed in research focused on cellular metabolism, nucleotide synthesis, and the mechanisms of antifolate drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Precursor for Derivatives: Utilized for the chemical modification and creation of novel compounds with potential biological activity.
• Nutritional Research: Applied in advanced studies exploring the role of reduced folates in cellular function and health.

Basic Information

Product Name	Tetrahydrohomofolic Acid
CAS No.	5786-82-3
Molecular Formula	C20H25N7O6
Molecular Weight	459.46 g/mol
Synonyms	5,6,7,8-Tetrahydrohomofolic Acid; Homotetrahydrofolic Acid; NSC 139490; THHFA; Tetrahydrohomo folate; (2S)-2-[[4-[[(2-Amino-5,6,7,8-tetrahydro-4-oxo-1H-pteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid
EINECS	Contact for details

Quality Control

Our Tetrahydrohomofolic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and identification by spectroscopic methods. Certificates of Analysis (COA) documenting full specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.