Description

1,2-Diarachidonoyl-Glycero-3-Phosphoethanolamine is a specialized phospholipid derivative, specifically a diarachidonoyl-substituted phosphatidylethanolamine. This compound is a critical biochemical tool and a key intermediate in lipid signaling research, particularly in the study of endocannabinoid and eicosanoid pathways. It is essential for researchers and manufacturers in the pharmaceutical and life science sectors who require high-purity, structurally-defined lipids for analytical standards, biochemical assays, and the investigation of membrane dynamics and cellular signaling mechanisms.

Application

• Biochemical Research Standard: Serves as a high-purity reference standard for mass spectrometry (MS), nuclear magnetic resonance (NMR), and chromatography in lipidomics studies.
• Cell Signaling Studies: Used as a precursor or substrate in enzymatic assays to study the biosynthesis and metabolism of N-acylethanolamines (NAEs) and related signaling lipids.
• Lipid Membrane Research: Incorporated into liposome and bilayer models to investigate the role of polyunsaturated phospholipids on membrane fluidity, curvature, and protein interactions.
• Pharmaceutical Development: Employed as an intermediate or analytical marker in the research and development of therapeutics targeting lipid-mediated pathways, such as inflammation and neurological disorders.
• Enzymology: Acts as a specific substrate for phospholipases and other lipid-modifying enzymes to characterize enzyme activity and kinetics.

Basic Information

Product Name	1,2-Diarachidonoyl-Glycero-3-Phosphoethanolamine
CAS No.	5634-86-6
Molecular Formula	C47H75NO8P
Molecular Weight	813.07 g/mol
Synonyms	1,2-Di(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine; DAPE; AA-PE; Diarachidonoyl Phosphatidylethanolamine; 1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine; N/Arachidonoyl Phosphatidylethanolamine; PE(20:4/20:4); Phosphatidylethanolamine (20:4/20:4)
EINECS	Contact for details

Quality Control

Our 1,2-Diarachidonoyl-Glycero-3-Phosphoethanolamine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and integrity. Each lot undergoes comprehensive analytical characterization, including purity assay by HPLC, identity confirmation by spectroscopic methods (NMR, MS), and analysis of critical impurities such as oxidation products. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The material is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform, ethanol; slightly soluble in hexane
Peroxide Value	< 5 mEq/kg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.