Description

Phenylthiohydantoin-Aspartic Acid (CAS NO 5624-13-5) is a specialized derivative of aspartic acid, a key amino acid, modified with a phenylthiohydantoin moiety. This compound is of significant value in advanced biochemical research and analytical chemistry, particularly in the field of protein sequencing and peptide analysis. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and diagnostic manufacturers requiring high-purity reference standards and intermediates for sophisticated analytical methodologies.

Application

• Protein Sequencing Reagent: Used as a critical intermediate in the Edman degradation process for stepwise determination of amino acid sequences in peptides and proteins.
• Analytical Reference Standard: Serves as a high-purity standard for calibrating analytical instruments like HPLC and mass spectrometry in proteomics research.
• Biochemical Research: Employed in studies investigating amino acid metabolism, protein structure-function relationships, and post-translational modifications.
• Pharmaceutical Intermediate: Acts as a building block in the synthesis of more complex peptides or peptide-mimetic compounds for drug discovery programs.
• Diagnostic Kit Component: Utilized in the development of in-vitro diagnostic assays for detecting specific proteins or enzymatic activities.

Basic Information

Product Name	Phenylthiohydantoin-Aspartic Acid
CAS No.	5624-13-5
Molecular Formula	C₁₃H₁₂N₂O₃S
Molecular Weight	276.31 g/mol
Synonyms	PTH-Asp; PTH-Aspartic Acid; 3-[(Phenylamino)thioxomethyl]amino]-4-oxo-4-[(phenylamino)thioxomethyl]amino]butanoic Acid (IUPAC); Aspartic Acid Phenylthiohydantoin; Edman Degradation Product of Asp; (S)-2-Amino-3-[(phenylcarbamothioyl)amino]succinic acid; PTH-Derivative of L-Aspartic Acid
EINECS	Contact for details

Quality Control

Our Phenylthiohydantoin-Aspartic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the exacting standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.