Description

Betamethasone Acibutate is a synthetic glucocorticoid ester prodrug, specifically designed for enhanced topical and transdermal delivery. This compound is valued for its potent anti-inflammatory and immunosuppressive activity, offering a critical intermediate for advanced pharmaceutical formulations. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and cosmeceutical sectors developing targeted corticosteroid therapies.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the manufacture of high-potency topical corticosteroid medications.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to develop novel anti-inflammatory drug delivery systems, including creams, ointments, and patches.
• Dermatological Formulations: Serves as a critical component in the development of prescription-strength treatments for psoriasis, eczema, dermatitis, and other inflammatory skin conditions.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory treatments for skin conditions in animals.
• Reference Standard: Used in analytical laboratories for quality control testing, method development, and regulatory compliance (e.g., HPLC, LC-MS).

Basic Information

Product Name	Betamethasone Acibutate
CAS No.	5534-05-4
Molecular Formula	C₂₈H₃₇FO₇
Molecular Weight	504.59 g/mol
Synonyms	Betamethasone 17-Acibutate; 9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate 17-butyrate; Betamethasone 17-Butyrate 21-Acetate; Betamethasone Acetate Butyrate; NSC-112682; SQ-15102; Betamethasone 17α-Butyrate-21-acetate
EINECS	226-881-5

Quality Control

Our Betamethasone Acibutate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.