Description

(15β,16E)-16,17,20,21-Tetradehydro-16-(Hydroxymethyl)-18,19-Secoyohimban-19-Oic Acid Methyl Ester is a complex, semi-synthetic indole alkaloid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or reference standard for the development of novel therapeutic agents targeting the central nervous system. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules. The compound's unique structural framework makes it a valuable building block for medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex indole alkaloid-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold or precursor for designing and synthesizing new chemical entities (NCEs) with potential biological activity.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (e.g., HPLC, LC-MS).
• Biochemical Research: Investigated for its interaction with various biological targets, including receptors and enzymes, in preclinical studies.
• Process Development: Used in scaling up and optimizing synthetic routes for the production of related alkaloid derivatives.

Basic Information

Product Name	(15β,16E)-16,17,20,21-Tetradehydro-16-(Hydroxymethyl)-18,19-Secoyohimban-19-Oic Acid Methyl Ester
CAS No.	5523-49-9
Molecular Formula	C₂₂H₂₄N₂O₄
Molecular Weight	380.44 g/mol
Synonyms	Methyl (15β,16E)-16,17,20,21-tetradehydro-16-(hydroxymethyl)-18,19-secoyohimban-19-oate; 19-Carbomethoxy-16,17-didehydro-16-hydroxymethyl-18,19-secoyohimbane; 16-(Hydroxymethyl)-16,17-didehydro-18,19-secoyohimban-19-carboxylic Acid Methyl Ester; Secoyohimban Derivative; Yohimbine Related Compound; Indole Alkaloid Ester; 5523-49-9; 16-(Hydroxymethyl)-16,17-didehydro-18,19-secoyohimban-19-oic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (15β,16E)-16,17,20,21-Tetradehydro-16-(Hydroxymethyl)-18,19-Secoyohimban-19-Oic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity reference materials and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability. Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.