Description

β-Naadp Sodium Salt is a high-purity, water-soluble salt form of the potent intracellular calcium-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). This compound is critical for researchers investigating calcium signaling pathways, lysosomal function, and related physiological processes. It is primarily utilized by biochemists, molecular biologists, and pharmacologists in academic, pharmaceutical, and biotechnology R&D settings for target validation and mechanistic studies.

Application

• Biochemical Research: As a key tool compound for studying NAADP-sensitive calcium release channels, such as the two-pore channels (TPCs) in endolysosomal systems.
• Cell Signaling Studies: Investigating the role of NAADP as a second messenger in various cellular processes including fertilization, T-cell activation, and muscle contraction.
• Pharmacology & Drug Discovery: Used in high-throughput screening assays to identify novel agonists or antagonists of the NAADP pathway for potential therapeutic intervention.
• Enzymology: Serving as a substrate or modulator in studies of enzymes like ADP-ribosyl cyclases (CD38/CD157) that synthesize or degrade NAADP.
• Neuroscience Research: Exploring calcium signaling mechanisms in neuronal function, synaptic plasticity, and neurodegenerative disease models.
• Cardiovascular Research: Studying calcium-induced calcium release and its regulation in cardiac and smooth muscle cells.

Basic Information

Product Name	β-Naadp Sodium Salt
CAS No.	5502-96-5
Molecular Formula	C21H26N7NaO17P3
Molecular Weight	788.37 g/mol
Synonyms	Nicotinic Acid Adenine Dinucleotide Phosphate Sodium Salt; NAADP Sodium Salt; β-NAADP Na+ Salt; Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt, sodium salt; 2'-Phosphoadenosine-5'-diphosphoribosyl-3'-carboxylamide sodium salt; Calcium-mobilizing second messenger NAADP sodium salt
EINECS	Contact for details

Quality Control

Our β-Naadp Sodium Salt is manufactured under strict quality controls to ensure batch-to-batch consistency and high biological activity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment, supporting research reproducibility and compliance with good laboratory practice (GLP) standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to minimize freeze-thaw cycles and maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by UV)
Water Content (KF)	≤ 5%
Solubility	Soluble in water, buffer solutions
Biological Activity	Calcium release assay (cell-based or sea urchin egg homogenate)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.