Description

Harmane-1,2,3,4-Tetrahydro-3-Carboxylic Acid is a heterocyclic carboxylic acid derivative of the harmane alkaloid family, serving as a key synthetic intermediate and research chemical. This compound is valued for its role in the development of novel pharmacologically active molecules and advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, neuroscience research, and the synthesis of complex alkaloid analogs.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel β-carboline derivatives and other alkaloid-based compounds with potential therapeutic applications.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies targeting neurological receptors and enzymes.
• Neuroscience Studies: Employed in biochemical research to study the interactions of β-carbolines with neurotransmitter systems.
• Organic Synthesis: Serves as a versatile starting material for the preparation of more complex heterocyclic compounds and fine chemicals.
• Reference Standard: Used as an analytical standard in quality control laboratories for the identification and quantification of related substances.

Basic Information

Product Name	Harmane-1,2,3,4-Tetrahydro-3-Carboxylic Acid
CAS No.	5470-37-1
Molecular Formula	C₁₃H₁₄N₂O₂
Molecular Weight	230.26 g/mol
Synonyms	1,2,3,4-Tetrahydroharman-3-carboxylic acid; 3-Carboxy-1,2,3,4-tetrahydroharmane; 1-Methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid; Tetrahydroharman-3-carboxylic acid; 9H-Pyrido[3,4-b]indole-3-carboxylic acid, 1,2,3,4-tetrahydro-1-methyl-; Harmane-3-carboxylic acid, tetrahydro-; THHCA
EINECS	226-787-6

Quality Control

Our Harmane-1,2,3,4-Tetrahydro-3-Carboxylic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.