Description

(2β,5β,12S,19β)-15-[14,15-Dihydroeburnamenin-14α-Yl]-1-Methylaspidofractinine-3α-Carboxylic Acid Methyl Ester CAS NO 5263-34-3 is a complex indole alkaloid derivative, a high-purity reference standard and key intermediate of significant interest in advanced organic synthesis. Its intricate molecular framework makes it a valuable building block for pharmaceutical research and development, particularly in the study of bioactive natural product analogs. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-quality, well-characterized intermediates for drug discovery programs and process chemistry.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control, method validation, and analytical testing in drug development.
• Advanced Organic Synthesis Intermediate: Serves as a critical chiral building block for the total synthesis of complex indole alkaloids and novel therapeutic agents.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new compounds targeting neurological and other disorders.
• Biochemical Research: Utilized as a tool compound in pharmacological assays to investigate biological pathways and enzyme interactions.
• Process Development & Scale-up: Acts as a key intermediate in the pilot-scale and commercial-scale synthesis of active pharmaceutical ingredients (APIs).
• Academic Research: Used in university and institutional labs for studies in natural product chemistry, synthetic methodology, and alkaloid research.

Basic Information

Product Name	(2β,5β,12S,19β)-15-[14,15-Dihydroeburnamenin-14α-Yl]-1-Methylaspidofractinine-3α-Carboxylic Acid Methyl Ester
CAS No.	5263-34-3
Molecular Formula	C43H50N4O4
Molecular Weight	686.89 g/mol
Synonyms	Vincamine Impurity C; Vincamine Related Compound C; 14,15-Dihydro-14α-eburnamenine-15-yl 1-methylaspidofractinine-3α-carboxylate; Methyl (2β,5β,12α,19β)-15-[(14α)-14,15-dihydroeburnamenin-14-yl]-1-methylaspidofractinine-3α-carboxylate; Eburnamenin-14α-yl aspidofractinine derivative; 5263-34-3; Vincamine EP Impurity C
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data and can supply material that meets the requirements of relevant pharmacopoeial standards (e.g., EP) for impurity profiling upon request. Our commitment ensures material suitable for cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool, and well-ventilated place. Keep the container sealed to protect from moisture and contamination. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.