Description

Cloprednol is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties. This compound is a critical active pharmaceutical ingredient (API) for the development of specialized therapeutic formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of treatments for inflammatory and autoimmune conditions.

Application

• Pharmaceutical API: Serves as the key active ingredient in the formulation of corticosteroid medications.
• Anti-inflammatory Therapeutics: Used in the development of treatments for conditions like rheumatoid arthritis, asthma, and severe dermatological inflammations.
• Immunosuppressive Drugs: A component in formulations designed to manage autoimmune diseases and prevent organ transplant rejection.
• Ophthalmic Preparations: Employed in the research and production of steroid eye drops for treating ocular inflammation.
• Topical Creams and Ointments: Incorporated into dermatological products for targeted anti-inflammatory action.
• Veterinary Medicine: Used in the development of anti-inflammatory treatments for animals.
• Biochemical Research: Acts as a reference standard and a tool for studying glucocorticoid receptor activity and signaling pathways.
• Preclinical and Clinical Studies: Utilized in pharmaceutical R&D for efficacy and safety testing of new drug candidates.

Basic Information

Product Name	Cloprednol
CAS No.	5251-34-3
Molecular Formula	C21H27ClO5
Molecular Weight	394.89 g/mol
Synonyms	6-Chloro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione; 6α-Chloro-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; Cloprednolum; Syntestan; RS-4691; Cloprednone; 1,4-Pregnadiene-3,20-dione, 6-chloro-11,17,21-trihydroxy-, (6α,11β)-
EINECS	226-052-5

Quality Control

Our Cloprednol is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical intermediates and APIs. Quality is assured through comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available for every batch, confirming compliance with in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.