Description

Brinzolamide is a potent, non-competitive carbonic anhydrase inhibitor used as an active pharmaceutical ingredient (API). This compound is critical for the formulation of ophthalmic solutions designed to reduce elevated intraocular pressure. It is primarily required by pharmaceutical manufacturers and research institutions focused on developing treatments for conditions such as glaucoma and ocular hypertension. Our supply of Brinzolamide CAS NO 138890-50-3 ensures high purity and reliable consistency for your production needs.

Application

• Ophthalmic Pharmaceutical Formulations: Primary use as the active ingredient in prescription eye drops for glaucoma.
• Antiglaucoma Medications: Key component in drugs that lower intraocular pressure by reducing aqueous humor production.
• Ophthalmic Suspensions: Used in the development of sterile, micronized suspension formulations for topical ocular delivery.
• Pharmaceutical Research & Development (R&D): Serves as a reference standard and building block in ophthalmic drug discovery.
• Generic Drug Manufacturing: Essential for producing bioequivalent versions of branded antiglaucoma therapeutics.
• Combination Therapies: Used in fixed-dose combination products with other intraocular pressure-lowering agents.

Basic Information

Product Name	Brinzolamide
CAS No.	138890-50-3
Molecular Formula	C12H21N3O5S3
Molecular Weight	383.51 g/mol
Synonyms	(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; AL-4862; Azopt (Trade Name); 1,1-Dioxo-N-ethyl-6-methyl-4H-thieno[2,3-b]thiopyran-4-sulfonamide-6S; Brinzolamide; Carbonic Anhydrase II Inhibitor
EINECS	Contact for details

Quality Control

Our Brinzolamide is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality is assured through a comprehensive battery of tests including identification, assay, and impurity profiling. We provide full traceability and support regulatory submissions with compliant documentation. Certificates of Analysis (COA) are available upon request, detailing compliance with relevant pharmacopeial specifications such as USP or in-house analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from excessive heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 1.5%
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.