Description

5'-Tosyladenosine is a chemically modified nucleoside derivative where a tosyl group is introduced at the 5' position of the adenosine sugar moiety. This modification is critical for its role as a versatile synthetic intermediate and protecting group reagent in organic and medicinal chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for the development of novel nucleoside analogs, prodrugs, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Protecting Group Chemistry: The tosyl group serves as a protective group for hydroxyl functions during multi-step organic synthesis.
• Bioconjugation & Probe Development: Used in the preparation of labeled nucleotides and molecular probes for biochemical research.
• Enzyme Substrate & Inhibitor Studies: Employed in biochemical assays to study the activity of kinases, polymerases, and other nucleoside-processing enzymes.
• Precursor for Modified RNAs: Acts as a starting material for the synthesis of site-specifically modified oligonucleotides.
• Academic & Industrial R&D: Fundamental research tool in universities and corporate labs for exploring new chemical entities and reaction pathways.

Basic Information

Product Name	5'-Tosyladenosine
CAS No.	5135-30-8
Molecular Formula	C17H19N5O5S
Molecular Weight	405.43 g/mol
Synonyms	Adenosine, 5'-(4-methylbenzenesulfonate); 9-β-D-Ribofuranosyladenine 5'-(p-toluenesulfonate); 5'-O-Tosyladenosine; p-Toluenesulfonyl Adenosine; N6-(p-Toluenesulfonyl)adenosine (less common); Tosyl Ado; 5'-Tosyl-Ado; 5'-O-(4-Methylbenzenesulfonyl)adenosine
EINECS	225-881-8

Quality Control

Our 5'-Tosyladenosine is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for research and development applications. While specific pharmacopeial monographs may not apply, our standard quality commitment includes comprehensive analytical verification. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity (typically by HPLC), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.