Description

N1-Methyl-2'-Deoxyguanosine is a modified nucleoside where a methyl group is attached to the N1 position of the guanine base. This specific structural modification makes it a valuable biochemical tool and a critical intermediate in nucleic acid research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of nucleoside chemistry, epigenetics, and antiviral/anticancer drug discovery. The compound's role in studying DNA methylation and its analogs is essential for advancing therapeutic and diagnostic applications.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic studies related to DNA methylation and repair mechanisms.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Epigenetics Studies: Employed to investigate the biological effects and detection of specific methylated DNA bases.
• Diagnostic Development: Acts as a critical component in the development of assays and kits for detecting epigenetic modifications.
• Reference Standard: Used for calibration and quality control in analytical laboratories for HPLC, LC-MS, or NMR analysis.
• Academic & Industrial R&D: Fundamental material for exploring novel nucleic acid chemistries and modified oligonucleotides.

Basic Information

Product Name	N1-Methyl-2'-Deoxyguanosine
CAS No.	5132-79-6
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	1-Methyl-2'-deoxyguanosine; 1-Methyl-deoxyguanosine; N(1)-Methyl-2'-deoxyguanosine; 2'-Deoxy-N1-methylguanosine; 1-Methyl-2'-deoxy-guanosine; dG(1-Me); 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-6,9-dihydro-1H-purin-6-one
EINECS	Contact for details

Quality Control

Our N1-Methyl-2'-Deoxyguanosine is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, ensuring it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the material should be handled in a dry environment and consideration should be given to storage under inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.