Description

Crotanecine CAS NO 5096-50-4 is a pyrrolizidine alkaloid of significant interest in pharmaceutical and biochemical research. This compound serves as a crucial intermediate and reference standard for the study of hepatotoxic and genotoxic substances, enabling critical safety assessments. It is primarily utilized by research institutions, pharmaceutical development laboratories, and analytical service providers focused on toxicology, natural product chemistry, and drug safety evaluation.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the qualitative and quantitative analysis of pyrrolizidine alkaloids in herbal medicines, supplements, and food products.
• Toxicological Research: Serves as a key reagent in studies investigating the mechanisms of hepatotoxicity, genotoxicity, and carcinogenicity associated with pyrrolizidine alkaloid exposure.
• Biochemical Pathway Analysis: Employed in metabolic studies to understand the bioactivation and detoxification pathways of hepatotoxic alkaloids.
• Analytical Method Development: Essential for developing and validating sensitive analytical methods, such as LC-MS/MS and HPLC, for the detection of trace alkaloid contaminants.
• Natural Product Chemistry: Used as a building block or intermediate in the synthesis and structural elucidation of complex natural products.
• Quality Control & Safety Testing: Critical for compliance testing in industries requiring the absence of pyrrolizidine alkaloids, such as herbal product manufacturing and food safety.

Basic Information

Product Name	Crotanecine
CAS No.	5096-50-4
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	(+)-Crotanecine; Crotanecin; 1-Hydroxymethyl-7-hydroxy-2,3,5,7a-tetrahydro-1H-pyrrolizine; 7-Hydroxy-1-hydroxymethyl-2,3,5,7a-tetrahydro-1H-pyrrolizine; Retronecine derivative; PA intermediate; Pyrrolizidine alkaloid necine base
EINECS	Contact for details

Quality Control

Our Crotanecine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant guidelines for reference standard materials to support your compliance and research integrity needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity, the container should be kept under an inert atmosphere to prevent oxidation and moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.