Description

1-Methylyohimbine is a methylated derivative of the yohimbine alkaloid, known for its specific pharmacological profile and utility as a key reference standard in research and development. This compound is critical for scientists and manufacturers requiring high-purity intermediates for the synthesis of specialized pharmaceutical agents or for conducting precise biochemical studies. It is primarily sought by the pharmaceutical, biotechnology, and advanced chemical synthesis sectors for applications in neuroscience, metabolic research, and as a building block for novel therapeutic candidates.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control, method validation, and analytical testing in drug development and manufacturing.
• Neuroscience Research: Employed in preclinical studies to investigate interactions with adrenergic and serotonergic receptor systems.
• Metabolic Research: Serves as a tool compound in studies related to lipid metabolism and endocrine function.
• Chemical Synthesis: Acts as a high-purity intermediate or precursor in the synthesis of more complex alkaloid derivatives and potential drug candidates.
• Biochemical Assays: Utilized in in vitro assays to study enzyme inhibition, receptor binding affinity, and signal transduction pathways.
• Academic Research: Provides a critical material for universities and research institutions exploring natural product chemistry and pharmacology.

Basic Information

Product Name	1-Methylyohimbine
CAS No.	5057-80-7
Molecular Formula	C22H28N2O3
Molecular Weight	368.47 g/mol
Synonyms	Methyl Yohimbine; 17α-Hydroxy-20α-yohimban-16β-carboxylic acid methyl ester; 1-Methyl Yohimbine; 1-Methylajmalicine; Rauwolscine methyl ether; 1-Methyl-17α-hydroxy-20α-yohimban-16β-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1-Methylyohimbine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for assay and related substances, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards for research and pharmaceutical-grade materials to support your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.