Description

Dl -Metanephrine CAS NO 5001-33-2 is a synthetic catecholamine metabolite, specifically the racemic mixture of the 3-O-methylated derivative of norepinephrine and epinephrine. This compound serves as a crucial reference standard and intermediate in biochemical research and pharmaceutical development. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies involved in neurochemistry, endocrinology, and clinical assay development.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods in drug metabolism and pharmacokinetic (PK) studies.
• Clinical Diagnostics: Acts as a key calibrator and control in liquid chromatography-mass spectrometry (LC-MS/MS) assays for accurately quantifying metanephrines in plasma or urine, aiding in the diagnosis of pheochromocytoma and paraganglioma.
• Biochemical Research: Employed in studies investigating catecholamine metabolism, enzymatic activity of catechol-O-methyltransferase (COMT), and adrenergic signaling pathways.
• Analytical Chemistry: Serves as a high-purity standard for method development in HPLC and GC analyses within quality control laboratories.
• Diagnostic Kit Manufacturing: An essential raw material in the production of immunoassay kits and other in-vitro diagnostic (IVD) devices for endocrine testing.

Basic Information

Product Name	Dl -Metanephrine
CAS No.	5001-33-2
Molecular Formula	C10H15NO3
Molecular Weight	197.23 g/mol
Synonyms	DL-Metanephrine; (±)-Metanephrine; 3-O-Methylepinephrine; 4-[1-Hydroxy-2-(methylamino)ethyl]-2-methoxyphenol; 3-Methoxyepinephrine; Meta-noradrenaline; Racemic Metanephrine
EINECS	225-663-6

Quality Control

Our Dl -Metanephrine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including identity confirmation, purity assay, and impurity profiling to ensure it meets the stringent requirements for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Due to its sensitivity, the product should be stored under an inert atmosphere to prevent oxidation and kept in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.