Description

(2R,5R)-6,7-Didehydroaspidofractinine-3β-Carboxylic Acid Methyl Ester is a high-purity, structurally defined alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral building block and intermediate for the development of novel therapeutic agents and complex natural product analogs. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of complex indole alkaloids and potential active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and the design of new drug candidates targeting neurological and other disorders.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective synthetic routes due to its defined (2R,5R) configuration.
• Natural Product Synthesis: Vital intermediate for the total or semi-synthesis of Aspidosperma and related alkaloids.
• Reference Standard: Serves as an analytical standard for quality control and method development in laboratories analyzing complex alkaloid mixtures.
• Biochemical Research: Used in studies investigating alkaloid biosynthesis pathways and enzyme interactions.

Basic Information

Product Name	(2R,5R)-6,7-Didehydroaspidofractinine-3β-Carboxylic Acid Methyl Ester
CAS No.	5001-20-7
Molecular Formula	C₂₁H₂₄N₂O₂
Molecular Weight	336.43 g/mol
Synonyms	Methyl (2R,5R)-6,7-didehydroaspidofractinine-3β-carboxylate; 3β-Carbomethoxy-6,7-didehydroaspidofractinine; Aspidofractinine-3β-carboxylic acid methyl ester, 6,7-didehydro-, (2R,5R)-; Methyl 6,7-didehydroaspidofractinine-3β-carboxylate; (2R,5R)-3β-Methoxycarbonyl-6,7-didehydroaspidofractinine
EINECS	Contact for details

Quality Control

Our (2R,5R)-6,7-Didehydroaspidofractinine-3β-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee (by Chiral HPLC)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.