Description

6-Fluorouracil is a fluorinated pyrimidine analog with significant biochemical activity. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly in the study of antimetabolite chemotherapeutic agents. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity building blocks for active pharmaceutical ingredient (API) synthesis and analytical method development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of more complex fluorinated pyrimidine-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and tool compound in oncology research to study mechanisms of cell proliferation and apoptosis.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories (HPLC, GC, MS).
• Antimetabolite Studies: Fundamental for investigating thymidylate synthase inhibition and DNA/RNA synthesis interference in experimental models.
• Fine Chemical Synthesis: Employed in organic synthesis to introduce the fluorouracil moiety into novel chemical entities for drug discovery programs.

Basic Information

Product Name	6-Fluorouracil
CAS No.	591-36-6
Molecular Formula	C4H3FN2O2
Molecular Weight	130.08 g/mol
Synonyms	5-Fluorouracil (common misnomer); 5-Fluoro-2,4(1H,3H)-pyrimidinedione; 5-FU; Fluorouracil; 5-Fluoropyrimidine-2,4-dione; NSC 19893; Adrucil; Carac; Efudex; Fluoroplex
EINECS	209-705-2

Quality Control

Our 6-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances and residual solvents, to ensure it meets stringent specifications for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.