Description

5-β-Pregnan-17,21-Diol-3,20-Dione is a high-purity steroid intermediate of significant importance in pharmaceutical synthesis. This compound serves as a critical building block for the production of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development and production of corticosteroids and other therapeutic steroids.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of corticosteroid drugs, including hydrocortisone and its derivatives.
• Research & Development: Used in medicinal chemistry research for exploring new steroid-based therapeutic agents and metabolic pathways.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical Studies: Employed in studies investigating steroid hormone metabolism, enzyme activity, and receptor interactions.

Basic Information

Product Name	5-β-Pregnan-17,21-Diol-3,20-Dione
CAS No.	566-42-7
Molecular Formula	C21H32O4
Molecular Weight	348.48 g/mol
Synonyms	17,21-Dihydroxypregnane-3,20-dione; 5β-Pregnane-3,20-dione-17,21-diol; 17α,21-Dihydroxy-5β-pregnane-3,20-dione; 5β-Pregnan-17α,21-diol-3,20-dione; 17,21-Dihydroxy-5β-pregnan-3,20-dione; 5β,17α,21-Trihydroxypregnan-20-one; 3,20-Diketo-5β-pregnan-17,21-diol
EINECS	Contact for details

Quality Control

Our 5-β-Pregnan-17,21-Diol-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.