Description

7-Ketocholesterol is an important oxysterol and a key biomarker of cholesterol oxidation. This compound matters significantly in biochemical research as it serves as a primary indicator of oxidative stress and is implicated in various pathophysiological processes. It is needed by researchers and manufacturers in the pharmaceutical, life science, and diagnostic industries for use in studies related to atherosclerosis, neurodegenerative diseases, and aging.

Application

• Biochemical Research Standard: Used as a high-purity reference standard for the quantification of cholesterol oxidation products in biological samples via HPLC, GC-MS, or LC-MS.
• Oxidative Stress Studies: A critical reagent in investigating the role of oxysterols in cell signaling, inflammation, and apoptosis associated with oxidative damage.
• Pharmaceutical Development: Employed in the research and development of therapeutic agents targeting diseases linked to oxysterol activity, such as cardiovascular and neurological disorders.
• Diagnostic Kit Manufacturing: Serves as a key component in the calibration and validation of diagnostic assays and kits designed to measure oxidative stress markers.
• Food & Cosmetic Safety: Utilized as an analytical standard to assess cholesterol oxidation in food products, supplements, and cosmetic formulations to ensure safety and stability.
• Academic Research: Fundamental tool in university and institutional labs for studying lipid metabolism, cell biology, and the mechanisms of age-related diseases.

Basic Information

Product Name	7-Ketocholesterol
CAS No.	566-28-9
Molecular Formula	C27H44O2
Molecular Weight	400.64 g/mol
Synonyms	7-Oxocholesterol; 3β-Hydroxy-5-cholesten-7-one; Cholest-5-en-3β-ol-7-one; 7-KC; 7-Keto Cholesterol; 7-Oxo-cholesterol; 5-Cholesten-3β-ol-7-one
EINECS	209-293-7

Quality Control

Our 7-Ketocholesterol is produced and tested under strict quality management protocols. Each batch undergoes comprehensive analysis to ensure high purity and consistency, meeting the stringent requirements of research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided to guarantee traceability and batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.