Description

Naphazoline Hydrochloride is a white to off-white crystalline powder belonging to the class of imidazoline derivatives. It is a potent α-adrenergic agonist primarily valued for its vasoconstrictive properties. This active pharmaceutical ingredient is essential for manufacturers in the ophthalmic and nasal decongestant sectors, where consistent high purity is critical for formulation efficacy and safety. Its reliable performance makes it a key component in over-the-counter and prescription medications targeting congestion and redness.

Application

• Ophthalmic Solutions: Primary active ingredient in eye drops for the relief of ocular redness and minor irritation.
• Nasal Decongestants: Key component in nasal sprays and drops to relieve nasal congestion associated with allergies, colds, or sinusitis.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of more complex therapeutic agents.
• Veterinary Medicines: Used in formulations for treating conjunctival and nasal congestion in animals.
• Research & Development: Utilized in biochemical and pharmacological studies investigating adrenergic receptor activity.
• Contract Manufacturing: Supplied to CDMOs for the production of branded and generic decongestant products.

Basic Information

Product Name	Naphazoline Hydrochloride
CAS No.	550-99-2
Molecular Formula	C14H15ClN2 • HCl
Molecular Weight	246.74 g/mol
Synonyms	2-(1-Naphthylmethyl)-2-imidazoline Hydrochloride; Naphazoline HCl; Naphcon Active Ingredient; Privine Hydrochloride; Imidazoline, 2-(1-naphthylmethyl)-, monohydrochloride; 4,5-Dihydro-2-(1-naphthalenylmethyl)-1H-imidazole Hydrochloride; Albalon (as hydrochloride); EINECS 208-990-2
EINECS	208-990-2

Quality Control

Our Naphazoline Hydrochloride is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. We offer grades compliant with USP, EP, and BP monographs, with comprehensive testing for identity, purity, and impurities. A detailed Certificate of Analysis (COA) is provided with each batch, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Microbial Enumeration	Meets EP/USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.