Description

Neopyrithiamine Hydrobromide is a synthetic thiamine (vitamin B1) analog, widely recognized for its role as a potent and specific antagonist of thiamine-dependent enzymes. This compound is a critical research tool for studying thiamine metabolism, deficiency, and related neurological pathways. It is primarily utilized in biochemical research, pharmaceutical development, and as a reference standard in analytical laboratories.

Application

• Biochemical Research: Used as a specific inhibitor to study thiamine pyrophosphate (TPP)-dependent enzymatic processes, including transketolase and pyruvate dehydrogenase.
• Neurological Studies: Employed in creating experimental models of thiamine deficiency (e.g., Wernicke-Korsakoff syndrome) to investigate associated neuropathology and cognitive effects.
• Pharmaceutical R&D: Serves as a key intermediate or reference compound in the development of metabolic disorder treatments and vitamin-related therapeutics.
• Analytical Standard: Used as a high-purity reference standard in HPLC, LC-MS, and other chromatographic methods for quality control and method validation.
• Nutritional Science: Applied in studies investigating the molecular mechanisms of vitamin absorption, transport, and antagonism.

Basic Information

Product Name	Neopyrithiamine Hydrobromide
CAS No.	534-64-5
Molecular Formula	C₁₂H₁₆BrN₃OS
Molecular Weight	330.24 g/mol
Synonyms	Neopyrithiamine HBr; Pyrithiamine Hydrobromide; 2-Butyl-4-methyl-5-pyrimidinylmethyl (2-hydroxyethyl)dimethylammonium Bromide; Thiamine Antagonist; Vitamin B1 Antagonist; Amprolium Precursor; 1-(4-Amino-2-butyl-5-pyrimidinylmethyl)-2-methylpyridinium Bromide Hydrobromide
EINECS	208-607-2

Quality Control

Our Neopyrithiamine Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.