Description

D-Desthiobiotin is a key intermediate and derivative of biotin, a vital B-complex vitamin. This compound is essential for research and development in biochemistry and molecular biology, particularly in the study of biotin-dependent enzymes and metabolic pathways. It serves as a critical building block for pharmaceutical synthesis, diagnostic reagent formulation, and advanced nutritional research, meeting the stringent purity demands of high-value industrial and scientific applications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of biotin (Vitamin B7) and its various pharmaceutical-grade analogs.
• Biochemical Research: Used as a research tool in enzymology to study avidin-biotin binding and the function of biotin-dependent carboxylases.
• Diagnostic Reagents: Employed in the development of immunoassays and diagnostic kits that utilize biotin-streptavidin technology for signal amplification.
• Cell Culture & Microbiology: Acts as a defined growth factor in specialized cell culture media and for studying microbial biotin metabolism.
• Nutritional Science: Serves as a reference standard and material for investigating biotin's role in metabolism and potential fortification strategies.

Basic Information

Product Name	D-Desthiobiotin
CAS No.	533-48-2
Molecular Formula	C10H18N2O3
Molecular Weight	214.26 g/mol
Synonyms	D-Desthiobiotin; (+)-Desthiobiotin; D-α-(5,6-Cis-dihydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl)valeric Acid (desthiobiotin form); (3aS,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric Acid (desthiobiotin form); Biotin Desthio; Vitamin H Desthio Derivative; Biotin Intermediate
EINECS	208-571-2

Quality Control

Our D-Desthiobiotin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets high-purity standards suitable for research and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	+20.0° to +24.0° (c=1 in 0.1N NaOH)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.