Description

[R,(-)]-1,2,3,4-Tetrahydro-6,7-Dimethoxy-1-Methylisoquinolin-8-Ol is a chiral tetrahydroisoquinoline derivative, a key synthetic intermediate and building block in organic chemistry. Its value lies in its stereochemistry and functional groups, which are critical for constructing complex molecules with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of alkaloid-based therapeutics, chiral catalysts, and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral building block for the synthesis of potential drug candidates, particularly in the development of alkaloid-inspired therapeutics targeting the central nervous system.
• Asymmetric Synthesis: Used as a precursor or ligand in the development of chiral catalysts for stereoselective chemical reactions.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in laboratories.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of complex natural product analogs and specialty chemicals.

Basic Information

Product Name	[R,(-)]-1,2,3,4-Tetrahydro-6,7-Dimethoxy-1-Methylisoquinolin-8-Ol
CAS No.	529-58-8
Molecular Formula	C₁₂H₁₇NO₃
Molecular Weight	223.27 g/mol
Synonyms	(-)-Salsolinol; (R)-(-)-Salsolinol; (R)-1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; (R)-1-Methyl-1,2,3,4-tetrahydro-6,7-isoquinolinediol; 1(R)-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; 6,7-Dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (R-enantiomer); (R)-THIQ derivative
EINECS	Contact for details

Quality Control

Our [R,(-)]-1,2,3,4-Tetrahydro-6,7-Dimethoxy-1-Methylisoquinolin-8-Ol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) specifying identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (R-enantiomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.