Description

Dichloromethotrexate is a halogenated derivative of the classic antifolate agent methotrexate, offering distinct chemical properties for advanced research and development. This compound is valued for its role as a key intermediate in the synthesis of novel therapeutic agents and biochemical probes. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and specialty chemical manufacturers focused on oncology and immunology applications.

Application

• Pharmaceutical Intermediate: A critical building block in the research and synthesis of next-generation antifolate drugs and targeted therapies.
• Biochemical Research: Used as a tool compound to study dihydrofolate reductase (DHFR) inhibition mechanisms and cellular folate metabolism.
• Anticancer Agent Development: Serves as a precursor for developing novel chemotherapeutic candidates with potentially altered pharmacokinetic profiles.
• Immunosuppressant Research: Investigated for its potential in modulating immune responses in autoimmune disease research models.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Organic Synthesis: Utilized in specialized organic reactions where a halogenated methotrexate analog is required for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Dichloromethotrexate
CAS No.	528-74-5
Molecular Formula	C₂₀H₂₂Cl₂N₈O₅
Molecular Weight	501.34 g/mol
Synonyms	4-Amino-10-methylpteroyl-3',5'-dichloroglutamic acid; 3',5'-Dichloroamethopterin; 3',5'-Dichloromethotrexate; Dichloroamethopterin; NSC-139105; 4-Amino-4-deoxy-10-methylpteroyl-3',5'-dichloro-L-glutamic acid; L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-3,5-dichloro-
EINECS	Contact for details

Quality Control

Our Dichloromethotrexate is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.