Description

Isoretronecanol is a pyrrolizidine alkaloid derivative, a versatile chiral building block and intermediate in organic synthesis. Its unique fused bicyclic structure makes it a valuable precursor for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs), natural product analogs, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of tropane alkaloids and other pharmacologically active nitrogen-containing heterocycles.
• Agrochemical Research: Used as a precursor in the development of novel pesticides and herbicides that leverage its alkaloid backbone.
• Natural Product Synthesis: Serves as a building block for the total or semi-synthesis of complex natural products and their derivatives for biological evaluation.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and as a scaffold for designing new molecular probes and drug candidates.
• Academic & R&D Laboratories: A valuable reagent for methodological development in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	Isoretronecanol
CAS No.	526-63-6
Molecular Formula	C8H15NO
Molecular Weight	141.21 g/mol
Synonyms	1-Hydroxymethyl-8-methyl-8-azabicyclo[3.2.1]octane; 8-Methyl-8-azabicyclo[3.2.1]octan-3α-ol; Isoretronecan-3α-ol; 3α-Hydroxytropane; 3-endo-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane; Pseudotropine alcohol
EINECS	208-395-5

Quality Control

Our Isoretronecanol is produced under a strict quality management system to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC/GC purity, chiral purity, and identity confirmation (IR, NMR). A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. For custom synthesis or specific grade requirements (e.g., research grade, pharmaceutical intermediate grade), our technical team is available to discuss tailored quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (by chiral HPLC or GC)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.