Description

Cinchonidine Hydrochloride is a high-purity alkaloid salt derived from cinchona bark, valued for its role as a chiral resolving agent and asymmetric catalyst. Its primary commercial significance lies in enabling the synthesis of enantiomerically pure compounds, which are critical for pharmaceutical efficacy and safety. This product is essential for research laboratories and industrial-scale manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors requiring precise stereochemical control.

Application

• Chiral Resolution Agent: Used for the separation of racemic mixtures of carboxylic acids and other chiral compounds in pharmaceutical intermediate synthesis.
• Asymmetric Catalysis: Serves as a chiral ligand or catalyst in stereoselective organic reactions, such as asymmetric hydrogenations and alkylations.
• Pharmaceutical Reference Standard: Employed as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Biochemical Research: Utilized in studies of enzyme inhibition and as a tool compound in pharmacological research due to its interaction with specific biological targets.
• Fine Chemical Synthesis: A key building block for the preparation of more complex, optically active molecules in specialty chemistry.

Basic Information

Product Name	Cinchonidine Hydrochloride
CAS No.	524-57-2
Molecular Formula	C19H22N2O · HCl
Molecular Weight	322.85 g/mol (Free base: 294.39)
Synonyms	(8S,9R)-Cinchonan-9-ol hydrochloride; Cinchonan-9-ol, hydrochloride, (8alpha,9R)-; Cinchonidine HCl; (8α,9R)-Cinchonan-9-ol Hydrochloride; α-Quinidine Hydrochloride; Cinchotine Hydrochloride; Contact for details on additional trade names.
EINECS	208-353-7

Quality Control

Our Cinchonidine Hydrochloride is manufactured under a strict quality management system. Each batch is tested to ensure it meets high-purity standards suitable for research and industrial applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0% (anhydrous basis)
Specific Rotation [α]20/D	-109° to -115° (c=1 in H2O)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.