Description

Cinchonine Hydrochloride CAS NO 524-55-0 is a high-purity alkaloid salt derived from cinchona bark, valued for its chiral properties and biological activity. This compound serves as a critical intermediate and chiral selector in the synthesis of fine chemicals and pharmaceuticals. It is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, where precise stereochemistry is paramount.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of antimalarial and antiarrhythmic drugs.
• Chiral Resolution Agent: Used as a chiral selector in chromatography for the separation of enantiomers in analytical and preparative scales.
• Asymmetric Catalysis: Employed as a ligand or catalyst precursor in asymmetric synthesis to induce chirality in target molecules.
• Biochemical Research: Utilized in studies of enzyme inhibition, receptor binding, and other biological mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in laboratories.
• Agrochemical Synthesis: Intermediate in the production of certain chiral pesticides and herbicides.

Basic Information

Product Name	Cinchonine Hydrochloride
CAS No.	524-55-0
Molecular Formula	C19H22N2O • HCl
Molecular Weight	322.85 g/mol
Synonyms	Cinchonine HCl; (8α,9R)-Cinchonan-9-ol Hydrochloride; Cinchonine Monohydrochloride; Cinchonine Hydrochloride Dihydrate; α-(5-Vinyl-2-quinuclidinyl)-4-quinolinemethanol Hydrochloride; Cinchonan-9-ol, Hydrochloride, (8α,9R)-; NSC 199935
EINECS	208-353-1

Quality Control

Our Cinchonine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards for research and industrial use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0% (anhydrous basis)
Loss on Drying	≤1.0%
Specific Rotation [α]20/D	-110° to -118° (c=1 in H2O)
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.