Description

Dimenhydrinate CAS NO 523-87-5 is a well-established pharmaceutical active ingredient belonging to the ethanolamine class of antihistamines. It is a critical compound for the formulation of effective antiemetic and antivertigo medications, providing relief from nausea, vomiting, and dizziness associated with motion sickness and other conditions. This high-purity active pharmaceutical ingredient (API) is essential for manufacturers in the pharmaceutical industry developing solid oral dosage forms such as tablets and capsules.

Application

• Pharmaceutical API: Primary active ingredient in prescription and over-the-counter (OTC) anti-nausea and antivertigo medications.
• Motion Sickness Prevention: Formulated into tablets, chewables, and orally disintegrating strips for the prevention and treatment of nausea caused by travel.
• Vertigo Management: Used in therapeutic formulations to alleviate symptoms of dizziness and balance disorders, including those associated with Meniere's disease.
• Post-Operative & Chemotherapy-Induced Nausea: Employed as an antiemetic agent to control nausea and vomiting in clinical settings, though often in combination with other agents.
• Veterinary Pharmaceuticals: Incorporated into medications for preventing motion sickness in pets during transport.

Basic Information

Product Name	Dimenhydrinate
CAS No.	523-87-5
Molecular Formula	C24H28ClN5O3
Molecular Weight	469.96 g/mol
Synonyms	Dimenhydrinate; 2-(Diphenylmethoxy)-N,N-dimethylethylamine 8-chlorotheophyllinate; Dramamine (trade name); Diphenhydramine theoclate; Amdram; Andrumin; Antemin; Anautin; Chloranautine; Diamarin; Dimenest; Dimate; Dimenhydrinate; Gravol; Nauseatol; Novamina; Travel-Gum; Vomex A; Xamamina
EINECS	208-353-3

Quality Control

Our Dimenhydrinate is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP, EP, and BP. Every batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical use. A Certificate of Analysis (COA) documenting all test results is provided with each shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.