Description

Tetrahydroberberine is a hydrogenated derivative of the natural alkaloid berberine, offering distinct chemical and pharmacological properties. This compound is valued for its enhanced bioavailability and stability profile compared to its parent molecule, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily sought by manufacturers and research institutions in the pharmaceutical, nutraceutical, and life science sectors for developing novel therapeutic agents and high-purity reference standards.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel therapeutic agents targeting metabolic and neurological pathways.
• Biochemical Research: Used as a reference standard and active probe in pharmacological studies and mechanism of action research.
• Nutraceutical Formulation: Incorporated into advanced dietary supplements for its potential bioactivity and improved absorption characteristics.
• Reference Standard: Serves as a high-purity calibration standard for analytical methods in quality control laboratories.
• Preclinical Development: Employed in animal studies and early-stage drug development due to its modified pharmacokinetic profile.

Basic Information

Product Name	Tetrahydroberberine
CAS No.	522-97-4
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Canadine; 5,6,13,13a-Tetrahydro-9,10-dimethoxy-6-methyl-[1,3]benzodioxolo[5,6-c]-2,3,9,10-tetrahydroprotoberberine; Tetrahydroberberine; (13aS)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6-methyl-[1,3]benzodioxolo[5,6-c]berbin-3-ol; NSC 172896; THB
EINECS	208-320-5

Quality Control

Our Tetrahydroberberine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets stringent specifications for research and production use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.