Description

16α-Chloromethylyohimban-17α-Ol is a specialized indole alkaloid derivative of significant interest in advanced organic synthesis. This compound serves as a critical synthetic intermediate for the development of novel pharmaceutical agents and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical development companies engaged in the synthesis of complex alkaloids and potential therapeutic compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex yohimbine analogs and other indole alkaloid-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a precursor for structure-activity relationship (SAR) studies to develop new compounds with targeted biological activity.
• Organic Synthesis: Serves as a versatile chiral intermediate for constructing complex polycyclic frameworks in total synthesis projects.
• Biochemical Research: Potential tool compound for studying adrenergic receptor interactions and related neurological pathways.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	16α-Chloromethylyohimban-17α-Ol
CAS No.	522-71-4
Molecular Formula	C20H23ClN2O
Molecular Weight	342.86 g/mol
Synonyms	16α-(Chloromethyl)-17α-hydroxyyohimban; 17α-Hydroxy-16α-(chloromethyl)yohimban; 16α-Chloromethyl-17α-hydroxyyohimban; Yohimban-17α-ol, 16α-(chloromethyl)-; (16α,17α)-16-(Chloromethyl)-17-hydroxyyohimban; 16-Chloromethyl-17-hydroxyyohimban; 16α-Chloromethyl-17α-hydroxy-yohimban
EINECS	Contact for details

Quality Control

Our 16α-Chloromethylyohimban-17α-Ol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support cGMP-grade production for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.