Description

(1R,7S,8R)-7-(Hydroxymethyl)-2,3,5,6,7,8-Hexahydro-1H-Pyrrolizin-1-Ol is a high-purity, stereochemically defined pyrrolizidine alkaloid derivative. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, valued for its unique fused bicyclic structure and functional groups. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), natural product analogs, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of potential therapeutic agents.
• Natural Product Synthesis: Used in the semi-synthesis or total synthesis of complex pyrrolizidine alkaloids and related natural products.
• Asymmetric Catalysis Research: Employed as a precursor or ligand in the development of new catalytic systems.
• Chemical Biology & Medicinal Chemistry: Serves as a scaffold for constructing compound libraries to probe biological pathways and identify drug candidates.
• Reference Standard: Used as an analytical standard in quality control and method development for related compounds.
• Academic Research: Fundamental studies in organic chemistry, stereochemistry, and heterocyclic compound reactivity.

Basic Information

Product Name	(1R,7S,8R)-7-(Hydroxymethyl)-2,3,5,6,7,8-Hexahydro-1H-Pyrrolizin-1-Ol
CAS No.	520-62-7
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	7-(Hydroxymethyl)-1-hydroxyhexahydropyrrolizine; (+)-Trachelanthamidine; (1R,7S,8R)-1-Hydroxy-7-(hydroxymethyl)pyrrolizidine; D-Trachelanthamidine; 1-Hydroxy-7-(hydroxymethyl)pyrrolizidine; 7-(Hydroxymethyl)-1-pyrrolizidinol; 1α-Hydroxy-7β-(hydroxymethyl)pyrrolizidine
EINECS	208-300-9

Quality Control

Our (1R,7S,8R)-7-(Hydroxymethyl)-2,3,5,6,7,8-Hexahydro-1H-Pyrrolizin-1-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.