Description

Colchicide is a potent alkaloid derivative, structurally related to colchicine, known for its specific biological activity. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly in the study of microtubule dynamics and cell cycle inhibition. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors who require high-purity bioactive molecules for advanced therapeutic applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel therapeutic agents targeting inflammatory and proliferative diseases.
• Biochemical Research: Used as a reference standard and active compound in studies of mitosis, cytoskeleton function, and apoptosis.
• Life Science Reagent: Employed in cell biology assays to investigate mechanisms of action related to tubulin binding and polymerization inhibition.
• Fine Chemical Synthesis: A valuable precursor for the preparation of more complex colchicine analogues and derivatives with modified biological profiles.
• Academic & Contract Research: Utilized in university and CRO laboratories for fundamental and applied research in oncology and pharmacology.

Basic Information

Product Name	Colchicide
CAS No.	518-15-0
Molecular Formula	C21H23NO5
Molecular Weight	369.41 g/mol
Synonyms	Colchiceinamide; N-Deacetyl-N-(2,3,4-trimethoxybenzoyl)colchicine; Colchiceine Amide; Demecolcine Impurity; Colchicine Derivative; 3-Demethylthiocolchicine; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
EINECS	Contact for details

Quality Control

Our Colchicide is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and related substances, to meet the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.