Description

11-Beta,17-Alpha,21-Trihydroxy-5-α-Pregnane-3,20-Dione is a high-purity steroid derivative, also known as 5α-Dihydrocortisol, serving as a critical intermediate in advanced pharmaceutical synthesis. Its value lies in providing a structurally defined backbone for the research and development of novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery. This compound is essential for pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in steroid chemistry and hormone-related studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of more complex corticosteroid analogs and other bioactive steroid molecules.
• Research & Development: Used as a reference standard and starting material in medicinal chemistry for investigating structure-activity relationships (SAR) of steroid hormones.
• Biochemical Research: Employed in studies of glucocorticoid and mineralocorticoid receptor interactions and metabolic pathways.
• Fine Chemical Synthesis: Serves as a precursor for the production of specialized steroid derivatives used in various experimental and diagnostic applications.

Basic Information

Product Name	11-Beta,17-Alpha,21-Trihydroxy-5-α-Pregnane-3,20-Dione
CAS No.	516-41-6
Molecular Formula	C21H32O5
Molecular Weight	364.48 g/mol
Synonyms	5α-Dihydrocortisol; 5α-Pregnane-3,20-dione, 11β,17α,21-trihydroxy-; 11β,17α,21-Trihydroxy-5α-pregnane-3,20-dione; 5α-Hydrocortisone; Dihydrocortisol; 5α-DHC; 11β,17α,21-Trihydroxy-5α-pregnan-3,20-dione
EINECS	208-229-9

Quality Control

Our 11-Beta,17-Alpha,21-Trihydroxy-5-α-Pregnane-3,20-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.