Description

(1R,7As)-1-[[[(2S,3R)-2,3-Dihydroxy-2-Isopropylbutanoyl]Oxy]Methyl]Hexahydro-1H-Pyrrolizine 4-Oxide is a high-purity pyrrolizidine alkaloid derivative with a complex stereochemistry, making it a valuable chiral building block and reference standard. This compound is critical for research and development in pharmaceutical chemistry, particularly for its role in studying bioactive natural products and metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories and contract research organizations (CROs) focused on medicinal chemistry and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, purity assessment, and quantification of related alkaloids in drug development and quality control.
• Medicinal Chemistry Research: Serves as a key chiral intermediate or precursor in the synthesis of novel therapeutic agents, particularly in oncology and neurology research.
• Metabolic Pathway Studies: Employed in biochemical research to investigate the biosynthesis, metabolism, and biological activity of pyrrolizidine alkaloids.
• Analytical Method Development: Essential for developing and validating sensitive analytical methods, such as HPLC-MS or GC-MS, for the detection of alkaloids in complex matrices.
• Toxicology and Safety Assessment: Used in studies to understand the structure-activity relationships and potential hepatotoxicity of pyrrolizidine alkaloid derivatives.

Basic Information

Product Name	(1R,7As)-1-[[[(2S,3R)-2,3-Dihydroxy-2-Isopropylbutanoyl]Oxy]Methyl]Hexahydro-1H-Pyrrolizine 4-Oxide
CAS No.	510-19-0
Molecular Formula	C16H27NO6
Molecular Weight	329.39 g/mol
Synonyms	Loline 4-Oxide; Loline N-oxide; Festucine; Loline Oxide; (1R,7aβ)-1-[[[(2S,3R)-2,3-Dihydroxy-2-(1-methylethyl)butanoyl]oxy]methyl]octahydro-1H-pyrrolizine 4-oxide; 1-[[[(2S,3R)-2,3-Dihydroxy-2-isopropylbutanoyl]oxy]methyl]hexahydro-1H-pyrrolizine 4-oxide; 1H-Pyrrolizine-4-oxide, 1-[[[(2S,3R)-2,3-dihydroxy-2-(1-methylethyl)butanoyl]oxy]methyl]hexahydro-, (1R,7aβ)-
EINECS	208-108-5

Quality Control

Our (1R,7As)-1-[[[(2S,3R)-2,3-Dihydroxy-2-Isopropylbutanoyl]Oxy]Methyl]Hexahydro-1H-Pyrrolizine 4-Oxide is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets the exacting standards required for research and reference material applications. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.