Description

α-Colubrine CAS NO 509-44-4 is a naturally occurring alkaloid compound belonging to the strychnine family, known for its specific stereochemistry and biological activity. This compound is valued in research and development for its role as a key intermediate and reference standard in pharmacological studies. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for applications in neuroscience, medicinal chemistry, and analytical method development.

Application

• Pharmaceutical Research: Serves as a crucial intermediate or reference standard in the synthesis and study of complex alkaloids and potential therapeutic agents.
• Neuroscience Studies: Used as a biochemical tool to investigate receptor interactions and neurological pathways due to its structural similarity to other bioactive alkaloids.
• Analytical Chemistry: Employed as a high-purity certified reference material (CRM) for method validation, calibration, and quality control in HPLC, LC-MS, and other analytical techniques.
• Medicinal Chemistry: Acts as a scaffold or precursor for the design and development of novel compounds with targeted biological activity.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in organic chemistry, natural product isolation, and bioactivity screening.
• Biotechnology: May be used in the development of assays and screening platforms for drug discovery pipelines.

Basic Information

Product Name	α-Colubrine
CAS No.	509-44-4
Molecular Formula	C₂₂H₂₆N₂O₃
Molecular Weight	366.46 g/mol
Synonyms	α-Colubrine; Colubrine; (3S,12bS)-3-Ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-3,8-diol; Strychnidin-10-one, 2,3-dimethoxy-; 2,3-Dimethoxystrychnidin-10-one; NSC 146051; UNII-8S8B27529M
EINECS	Contact for details

Quality Control

Our α-Colubrine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.