Description

Gelsemine is a major indole alkaloid isolated from plants of the *Gelsemium* genus, known for its complex polycyclic structure and significant biological activity. This high-purity reference standard is critical for analytical research, quality control, and pharmacological studies, ensuring precise identification and quantification. It serves as an essential material for researchers and quality assurance professionals in the pharmaceutical, phytochemical, and academic sectors who require reliable, well-characterized compounds for their work.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and impurity profiling of gelsemine in drug substances and herbal preparations.
• Biochemical Research: Employed in pharmacological and toxicological studies to investigate its effects on neuronal ion channels and its mechanism of action.
• Natural Product Analysis: Serves as a critical marker compound for the quality control and standardization of *Gelsemium* extracts and related botanical products.
• Academic & Method Development: Utilized in universities and R&D labs for developing and validating analytical methods such as HPLC, LC-MS, and NMR.
• Chemical Synthesis Intermediate: Acts as a key starting material or intermediate for the semi-synthesis of novel derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Gelsemine
CAS No.	509-15-9
Molecular Formula	C20H22N2O2
Molecular Weight	322.40 g/mol
Synonyms	Gelsemine; Gelsemin; (3beta,16alpha,17beta,20alpha)-3,17-Dimethoxy-2-oxa-16-azapentacyclo[11.8.0.0³,¹¹.0⁴,⁹.0¹⁶,²⁰]henicosa-4,6,8,10,12-pentaen-21-one; 16,17-Didehydro-19,20-didehydro-17-methoxy-3-methoxy-4,18-secocuran-19,20-diol 18,20-Oxide; 3,17-Dimethoxy-2-oxa-16-azapentacyclo[11.8.0.0³,¹¹.0⁴,⁹.0¹⁶,²⁰]henicosa-4,6,8,10,12-pentaen-21-one
EINECS	Contact for details

Quality Control

Our Gelsemine is produced and handled under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and related substances, and is supplied with a detailed Certificate of Analysis (COA). We support compliance with relevant pharmacopeial and research standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.