Description

4-Chloromercuribenzoic Acid is a specialized organomercury compound primarily utilized as a key reagent in biochemical research and analytical chemistry. Its core value lies in its ability to act as a selective sulfhydryl (-SH) group modifier, making it essential for studying enzyme active sites and protein structure-function relationships. This product is critically needed by research institutions, pharmaceutical R&D laboratories, and diagnostic kit manufacturers for applications in proteomics and molecular biology.

Application

• Biochemical Research: Selective blocking agent for cysteine thiol groups in enzymes and proteins to investigate catalytic mechanisms and structural roles.
• Proteomics & Protein Chemistry: Tool for mapping and quantifying accessible sulfhydryl groups in complex protein samples.
• Pharmaceutical Development: Used in the study of drug-protein interactions, particularly for compounds targeting cysteine residues.
• Diagnostic Reagent Manufacturing: Component in the formulation of specific assay kits that rely on thiol group detection or modification.
• Enzyme Inhibition Studies: Reversible inhibitor for certain classes of enzymes (e.g., proteases, dehydrogenases) to elucidate their biological function.
• Material Science Research: Precursor or modifying agent in the synthesis of specialized organometallic materials and sensors.

Basic Information

Product Name	4-Chloromercuribenzoic Acid
CAS No.	59-85-8
Molecular Formula	C7H5ClHgO2
Molecular Weight	357.16 g/mol
Synonyms	p-Chloromercuribenzoic Acid; PCMB; (4-Carboxyphenyl)chloromercury; 4-Carboxybenzenemercuric Chloride; Mercury, chloro(4-carboxyphenyl)-; Benzoic acid, 4-(chloromercuri)-; Chloro(4-carboxyphenyl)mercury; PCMBA
EINECS	200-438-5

Quality Control

Our 4-Chloromercuribenzoic Acid is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including assay by titration and identification by FT-IR spectroscopy. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, heavy metal content (specifically mercury speciation), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and the presence of mercury, the container must be kept sealed and away from incompatible materials. Ensure storage areas comply with local regulations for handling organomercury compounds.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (Titration)	≥ 98.0 %
Melting Point	Decomposes > 200°C
Loss on Drying	≤ 0.5 %
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.