Description

Physostigmine Salicylate is a parasympathomimetic alkaloid derived from the Calabar bean, primarily recognized for its potent acetylcholinesterase inhibitory activity. This compound is critical for applications requiring precise modulation of cholinergic signaling pathways. It is an essential active pharmaceutical ingredient (API) and research chemical for the pharmaceutical, biotechnology, and life science sectors.

Application

• Pharmaceutical Active Ingredient (API): Used in the formulation of ophthalmic solutions for the treatment of glaucoma and to reverse the effects of certain toxins and drugs.
• Biochemical Research: A vital tool in neuroscience and pharmacology for studying acetylcholine metabolism, cholinergic receptors, and nerve agent antidotes.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical testing, method development, and quality control in laboratories.
• Life Science Reagents: Employed in cell culture and enzymatic assays to investigate cellular signaling and neurobiology.

Basic Information

Product Name	Physostigmine Salicylate
CAS No.	57-64-7
Molecular Formula	C15H21N3O2 • C7H6O3
Molecular Weight	413.45 g/mol
Synonyms	Eserine Salicylate; Physostigmine 2-Hydroxybenzoate; (3aR,8aS)-1,3a,8-Trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N,N-dimethylcarbamate 2-hydroxybenzoate; Eserine Salicylic Acid Salt; Physostol; Antilirium (brand name reference); Calabarine Salicylate; Isopilocarpine Salicylate (historical)
EINECS	200-347-9

Quality Control

Our Physostigmine Salicylate is manufactured and tested under strict quality management systems. We provide material suitable for research and pharmaceutical development, with specifications that can meet relevant pharmacopeial standards (e.g., USP, EP) upon request. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.