Description

Demecarium Bromide is a potent, long-acting cholinesterase inhibitor belonging to the quaternary ammonium class of compounds. Its primary commercial value lies in its application as an active pharmaceutical ingredient (API) in ophthalmic solutions for the treatment of glaucoma and other conditions requiring sustained miosis. This high-purity compound is essential for manufacturers in the pharmaceutical sector, particularly those developing and producing specialized ophthalmic medications, where consistent quality and reliable supply are critical.

Application

• Active Pharmaceutical Ingredient (API) in ophthalmic solutions for the management of chronic glaucoma.
• Key component in miotic eye drops used to constrict the pupil during and after ocular surgery.
• Used in veterinary ophthalmology for similar therapeutic purposes in animals.
• Intermediate in the synthesis of more complex cholinergic agents for research and development.
• Reference standard in analytical laboratories for quality control and method validation.
• Pharmacological research tool for studying acetylcholinesterase inhibition and parasympathetic nervous system effects.

Basic Information

Product Name	Demecarium Bromide
CAS No.	56-94-0
Molecular Formula	C32H52Br2N4O4
Molecular Weight	716.60 g/mol
Synonyms	Humorsol; BC-48; Tosmilen; Demecarium Bromide; (3,3'-(1,10-Decanediyldi-1(1H)-pyridinyl-3,1-diyl)bis(oxy))bis(N,N,N-trimethyl-1-propanaminium) dibromide; 3,3'-(Decamethylenebis(oxy-p-phenylenecarbonylimino-m-phenyleneoxy))bis(N,N,N-trimethylpropan-1-aminium) dibromide
EINECS	200-295-8

Quality Control

Our Demecarium Bromide is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical use. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results against relevant pharmacopeial standards (such as USP/EP monographs where applicable) is provided to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.