Description

3-Methylcholanthrene is a potent polycyclic aromatic hydrocarbon (PAH) widely recognized in biochemical and toxicological research. Its primary value lies in its role as a powerful carcinogenic agent and a model compound for studying metabolic activation, DNA adduct formation, and chemical carcinogenesis. This high-purity compound is essential for researchers and laboratories in the pharmaceutical, environmental science, and academic sectors who require a reliable standard for mechanistic studies and toxicity screening.

Application

• Biochemical Research: Used as a model carcinogen to study the mechanisms of tumor initiation and promotion.
• Toxicology Studies: Serves as a positive control in assays for mutagenicity and genotoxicity (e.g., Ames test).
• Metabolic Pathway Analysis: Investigated for its metabolic activation by cytochrome P450 enzymes to form reactive intermediates.
• Environmental Contaminant Modeling: Acts as a representative PAH in studies of environmental pollution and human exposure risk assessment.
• Oncology Research: Employed in experimental models to induce tumors and study cancer development processes.
• Analytical Standard: Used as a high-purity reference standard in chromatography (HPLC, GC) for the identification and quantification of PAHs.

Basic Information

Product Name	3-Methylcholanthrene
CAS No.	56-49-5
Molecular Formula	C21H16
Molecular Weight	268.36 g/mol
Synonyms	3-MCA; 20-Methylcholanthrene; 3-Methyl-1,2-cyclopentenophenanthrene; 1,2-Dihydro-3-methylbenz[j]aceanthrylene; NSC 21970; 3-Methylcholanthren; 3-MC
EINECS	200-279-6

Quality Control

Every batch of our 3-Methylcholanthrene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay purity and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent contamination and degradation.

Specification

Item	Specification
Appearance	Yellow to pale brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	178°C - 182°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.